NextDose Bayesian forecasting dose calculator

A free web-based dose calculator using concentration guided dosing with Bayesian forecasting and the target concentration intervention approach
for busulfan, methotrexate, tacrolimus, warfarin, linezolid, voriconazole, gentamicin, tobramycin, amikacin, vancomycin, caffeine, mycophenolate, hydroxychloroquine, dabigatran, posaconazole, gancyclovir/valgancyclovir, clozapine and enoxaparin.

25-Jan-2026: NextDose Version Change to 2.5.01
- Prediction of CssTrough dose now uses observations known at the time of the last dependent variable observation (i.e. drug concentration or drug effect) rather than the time of the last observation of any type. This means the same set of PKPD parameters are used for all target types.

15-Jan-2026: NextDose Version Change to 2.5.00:
- Feature: Busulfan model can estimate lagtime due to infusion deadspace volume, oral absorption lagtime and bioavailability parameters improved.
- Bug fix for covariate effects on oral bioavailability (dabigatran).
- Bug fix for target report in Results when Csstrough is requested.

21-Oct-2025: NextDose Version Change to 2.4.14
- Daily data records tracking change in post-menstrual age and post-natal age.

18-Oct-2025: NextDose Version Change to 2.4.13
- Additional events tracking change in post-menstrual age and post-natal age. br>
- Feedback, and the reporting of any issues encountered, is always appreciated.

NextDose Updates

Anyone may sign up for single user access. Access to share patient data within a secure group can be applied for here.

Note that patient data stored on dev.nextdose.org is not transferable to www.nextdose.org. The dev.nextdose.org web is under active development and may change without notice as features are tested and bugs fixed.